Article 16222

Title of the article

The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia 

Authors

Tat'yana I. Vlasova, Doctor of medical sciences, associate professor, head of the sub-department of normal and pathological physiology, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: v.t.i@bk.ru
Vladimir A. Trofimov, Doctor of biological sciences, professor, head of the sub-department of genetics and genetic engineering, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: geneticlab@yandex.ru
Ekaterina V. Arsent'eva, Candidate of medical sciences, associate professor, associate professor of the sub-department of normal and pathological physiology, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: ev.arsenteva@yandex.ru
Anastasiya V. Sitdikova, Postgraduate student, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: ansit96@mail.ru
Tat'yana I. Shishkanova, Clinical resident of the sub-department of obstetrics and gynecology, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), E-mail: shishkt@yandex.ru 

Abstract

Background. To study the frequency of the fibrinogen gene (G(–455)A) FGB polymorphisms in pregnant women with hypercoagulemia in severe preeclampsia (PE). Materials and methods. On the basis of the perinatal center of the “Mordovia Republican Central Clinical Hospital” from 2015 to 2020, a prospective study of 2 groups of pregnant women aged 18 to 40 years was conducted for a period from 22 to 41 weeks of gestation: group I (control) – 52 women with physiological course of pregnancy, group II (main) – 58 patients with severe PE. A complex of studies was carried out, including: clinical, laboratory (complet blood count, hemostasiogram), special methods (genotyping of polymorphisms of the investigated fibrinogen gene FGB (G(–455)A) by PCR-method Real-time PCR), as well as thromboelastography of whole blood and assessment of microcirculation peripheral tissues. Results. In pregnant women with severe preeclampsia, a high prevalence of heterozygous (C/A) and homozygous (A/A) variants (48.3 and 36.2 %) of the FGB fibrinogen gene (G(–455)A), a pronounced imbalance between the processes fibrinogenesis and fibrinolysis, an increase in the amount of fibrinogen, as well as a decrease in the content of antithrombin III and the number of platelets, the pathological nature of thrombus formation and an increased relative strength and rate of blood clot formation were noted. Conclusions. The data obtained indicate the important role of the fibrinogen gene polymorphism (G(–455)A) FGB) in the implementation of the pathological hypercoagulability pathogenesis in severe preeclampsia, which contributes to the occurrence of vascular microthrombosis and further aggravation of endothelial damage and the progression of microcirculatory disorders. 

Key word

hemostasis system, genotype, polymorphism, preeclampsia 

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For citation:

Vlasova T.I., Trofimov V.A., Arsent'eva E.V., Sitdikova A.V., Shishkanova T.I. The role of genetic features of coding fibrinogen in microcirculatory disturbance in hypercoagulemia. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2022;(2):156–165. (In Russ.). doi:10.21685/2072-3032-2022-2-16

 

Дата создания: 22.06.2022 08:39
Дата обновления: 22.06.2022 10:21